The George Mason Schar School of Policy and Government for Entrepreneurship and Public Policy is a global leader in promoting knowledge development in public and private enterprises at the national, regional, and international levels. It is distinguished by a three-pronged educational and research focus on entrepreneurship opportunities in the technology, international, and federal sectors. The center places special emphasis on the role entrepreneurship plays in regional economic development by jointly sponsoring annual conferences on the subject in Amsterdam and Jonkoping, Sweden. It also hosts its own annual conference at George Mason University in conjunction with the School of Management.

The center applies the themes of the George Mason Schar School of Policy and Government while leveraging the resources of other departments in the university, including the School of Management, the College of Arts and Sciences, and Nursing and Health Science, among others. The center has a wide-ranging consulting service that works for clients in China, India, and the European Union on projects such as technology incubation and business development.